Precision
medicines
for
translational
dysfunction
01
Reprogramming how genes are turned into proteins to fight disease and restore human health.
DNA
transcription
RNA
translation
Protein
RNA pathobiology remains an undrugged dimension of most human diseases
Cancer is a disease caused by translational dysfunction of multiple oncogenes
HOVANA: VISION
Leverage unprecedented insights into tRNA reprogramming to invent a new class of medicines that selectively block oncogene translation across pathways.
“Translational Dysfunction”
Oncogene
Translation
tRNA Operating System (tOS)
Integrating molecular, genetic, cellular, organismal and clinical observations to predict, profile and prosecute key molecular drivers of oncogene translation.
Target
Validation
Molecule
Design
Clinical
Translation
Target
Prioritization
Lead
Identification
DC
Nomination
IND-/CTA-
Enabling Studies
Clinical
Proof-of-Concept
01 / Establish targets
Functional genomics
tRNA modification profiling
Ribosome footprinting
Quantitative proteomics
02 / Build molecules
Structural visualization
Computational chemistry
DNA-encoded libraries (DELs)
Target selectivity screening
03 / Study the right patients
Complete genomic profiling (CGP)
Codon adaptation algorithms
Cell and tissue xenograft models
Target engagement and PD biomarkers
proposition
precision
A
future-proof
in
medicine
Visionaries dream.
Innovators create.
We are both.
© 2023 Hovana
