Precision

medicines

for

translational

dysfunction

01

Reprogramming how genes are turned into proteins to fight disease and restore human health.

DNA

transcription

RNA

translation

Protein

RNA pathobiology remains an undrugged dimension of most human diseases

Cancer is a disease caused by translational dysfunction of multiple oncogenes

HOVANA: VISION

Leverage unprecedented insights into tRNA reprogramming to invent a new class of medicines that selectively block oncogene translation across pathways.

“Translational Dysfunction”

Oncogene

Translation

tRNA Operating System (tOS)

Integrating molecular, genetic, cellular, organismal and clinical observations to predict, profile and prosecute key molecular drivers of oncogene translation.

Target

Validation

Molecule

Design

Clinical

Translation

Target

Prioritization

Lead

Identification

DC

Nomination

IND-/CTA-

Enabling Studies

Clinical

Proof-of-Concept

01 / Establish targets

Functional genomics

tRNA modification profiling

Ribosome footprinting

Quantitative proteomics

02 / Build molecules

Structural visualization

Computational chemistry

DNA-encoded libraries (DELs)

Target selectivity screening

03 / Study the right patients

Complete genomic profiling (CGP)

Codon adaptation algorithms

Cell and tissue xenograft models

Target engagement and PD biomarkers

proposition

precision

A

future-proof

in

medicine

Visionaries dream.

Innovators create.

We are both.

© 2023 Hovana

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